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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Human bone marrow-derived, pooled, allogeneic mesenchymal stromal cells manufactured from multiple donors at different times show comparable biological functions in vitro, and in vivo to repair limb ischemia

Fig. 5

A similar magnitude of reduction in muscle degeneration and improvement in angiogenesis in the ischemic limbs of mice following Stempeucel®-1 and Stempeucel®-1A treatment: a Treatment with Stempeucel®-1 and Stempeucel®-1A significantly protected muscle fiber loss of adductor and gastrocnemius muscles compared to vehicle control. b Protection from muscle weight loss was observed upon treatment with Stempeucel®-1 and Stempeucel®-1A compared to the vehicle-treated group. c–f Histological analysis of muscle section of the sham control, vehicle control, and Stempeucel-treated groups. Red arrow indicates vacuolar degeneration, green arrow—mononuclear cells infiltration. Yellow arrow—muscle necrosis and black arrow—muscle degeneration. Intramuscular administrations of Stempeucel®-1 and Stempeucel®-1A survive in ischemic limb tissue, secrete paracrine factors, and recruit or proliferate CD31 positive endothelial cells. Representative images of IHC staining for g–j mCD31; k–n HNA; o–r hVEGF; positive cells in limb muscles of sham control, vehicle control, and Stempeucel-treated animals at day 28. Positive areas are marked with black arrows. Photographs were taken at × 40 magnification, and the scale bar shows the 50 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512