Table 1 Baseline characteristics of the study populations in the 10 studies included in the meta-analysis
Author year | Regimen | Age (years) | Sample size (females) | BMI (kg/m2) | HbA1c (%) | FBG (mmol/l) | Type of diabetes | Duration of DM | Dose of injected cells | Mode of injection | Follow-up (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|
Carlsso n 2015 [23] | hBM-MSCs Control | 24±6 27±6 | 9(1) 9(4) | 23.3±3.3 22.5± 2.7 | None | None | TIDM | None | 2.75×106/kg | IV | 12 |
Yu 2011 [25] | hUC-MSCs Control | 19.67±2.58 14.83±8.18 | 6(3) 6(2) | 21.56±1.67 20.08± 3.48 | 10.53± 0.98 9.16± 3.30 | 8.23±2.12 8.08±1.83 | TIDM | ≦3months | 1×107 | IV | 9 |
Hu 2013 [26] | WJ-MSCs Control | 17.6±33.69 18.2±30.60 | 15(6) 14(6) | 20.9±14.33 21.3±15.71 | 6.85±2.87 6.79±3.14 | 5.7±1.71 5.4±1.64 | TIDM | ≦6months | (2.6±1.2)×107 | IV | 24 |
Zhang 2016 [24] | AD-MSCs Control | 22. 1 ± 6. 6 21. 6 ± 6. 8 | 16(7) 17(7) | 20.8 ±1.9 21.1±1.9 | 6.76±1.25 6.71±1.43 | 5.92 ±1.68 6.13 ±1.49 | TIDM | 3.5 ±2.9 (months) 3. 7 ± 5. 5 (months) | 1×107/kg | IV | 24 |
Bhansali 2017 [18] | ABM-MSCs ABM-MSCs Control | 47.9±18.9 44.6±8.9 51.7±13.3 | 10(2) 10(3) 10(4) | 28.8±4.4 27.9±4.5 26.4±3.8 | 6.8±0.3 6.8±0.8 6.5±0.5 | 5.8±0.8 6.0±0.8 6.1±1.0 | T2DM | 15.3±12.7(years) 10.2±1.3(years) 12.5±5.2(years) | (1.2±0.3)×109 | SPD artery Splenic artery | 12 |
Guan 2015 [17] | hUC-MSCs | 40.5 ± 9.21 | 6(0) | 23.7±0.71 | 8.55±1.45 | None | T2DM | 42.7±31.89(months) | (0.88±0.05)×106 | Elbow vein | 33.2±2.82 |
Liu 2014 [19] | WJ-MSCs | 52.9± 10.5 | 22(7) | 25.1 ± 2.4 | 8.20 ±1.69 | 7.53 ± 2.67 | T2DM | 8.7 ± 4.3(years) | 1×106/kg | Spleen artery | 12 |
Kong 2014 [28] | hUC -MSCs Control | 52.75± 12.69 | 8(3) 10(3) | 25.94± 4.11 26.75± 4.32 | 7.30±1.49 None | 9.17± 1.92 8.42±1.25 | T2DM | 6.87± 4.73(years) 11.4± 8.38 (years) | 1.8×106/kg | IV | 6 |
Hu 2016 [29] | WJ-MSCs Control | 52.43±4.88 53.21±8.22 | 31(14) 30(14) | 26.74±5.41 27.03±6.68 | 7.67±1.23 7.54±1.31 | 8.24±1.55 7.91±1.44 | T2DM | 8.93±5.67(years) 8.3±6.07 (years) | 1×106/kg | IV | 36 |
Jiang 2011 [30] | PD-MSCs | 66 | 10(3) | None | 9.8±2.2 | None | T2DM | 3–20(years) | 1.35 ×106/kg | IV | ≧3 |