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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration

Fig. 2

Intradiscal injection of iMSC-sEVs ameliorates the progression of IVDD and senescence of the NPCs in a rat model. a MRIs of the indicated groups were obtained at 8 weeks after needle puncture. b Pfirrmann MRI grade scores. c HE staining of IVDs in the indicated groups at 8 weeks after needle puncture. Scale bar, 1 mm. d The grading score of HE staining. e IF staining for P16 (red) at 4 weeks after needle puncture. DAPI was used to stain the nuclei. Scale bar, 1 mm. *P < 0.05 compared with the control group, #P < 0.05 compared with IVDD group, %P < 0.05 compared with IVDD+iMSC-sEVs group

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Stem Cell Research & Therapy

ISSN: 1757-6512