Table 2 List of the genes up- or downregulated (> 2 fold) in the iMSC-CdM + MFN1 siRNA group with respect to iMSC-CdM group

A01

ATP5A1

NM_004046

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

− 2.33

A03

ATP5C1

NM_005174

ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1

− 2.21

A04

ATP5F1

NM_001688

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1

− 2.29

A05

ATP5G1

NM_005175

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

− 2.44

A08

ATP5H

NM_006356

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d

− 2.03

A11

ATP5J2

NM_004889

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2

− 2.71

A12

ATP5L

NM_006476

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G

− 3.01

B02

COX4I1

NM_001861

Cytochrome c oxidase subunit IV isoform 1

− 2.22

B04

COX5B

NM_001862

Cytochrome c oxidase subunit Vb

− 2.03

B06

COX6A2

NM_005205

Cytochrome c oxidase subunit VIa polypeptide 2

2.32

B08

COX6C

NM_004374

Cytochrome c oxidase subunit Vic

− 2.3

C02

NDUFA1

NM_004541

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5 kDa

− 2.09

C03

NDUFA10

NM_004544

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42 kDa

− 2.09

C04

NDUFA11

NM_175614

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7 kDa

− 2.14

C06

NDUFA3

NM_004542

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9 kDa

− 2.89

C09

NDUFA6

NM_002490

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14 kDa

− 3.77

C10

NDUFA8

NM_014222

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19 kDa

− 2.57

C11

NDUFAB1

NM_005003

NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8 kDa

− 3.36

C12

NDUFB10

NM_004548

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22 kDa

− 2.52

D05

NDUFB6

NM_182739

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17 kDa

− 2.46

D06

NDUFB7

NM_004146

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18 kDa

− 2.66

D07

NDUFB8

NM_005004

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19 kDa

− 2.5

D08

NDUFB9

NM_005005

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22 kDa

− 2.02

D09

NDUFC1

NM_002494

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6 kDa

− 2.48

D10

NDUFC2

NM_004549

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5 kDa

− 24.21

D12

NDUFS2

NM_004550

NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49 kDa (NADH-coenzyme Q reductase)

− 2.02

E02

NDUFS4

NM_002495

NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18 kDa (NADH-coenzyme Q reductase)

− 3.19

E04

NDUFS6

NM_004553

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13 kDa (NADH-coenzyme Q reductase)

− 2.73

E06

NDUFS8

NM_002496

NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase)

− 2.36

E07

NDUFV1

NM_007103

NADH dehydrogenase (ubiquinone) flavoprotein 1, 51 kDa

− 2.46

F01

SDHC

NM_003001

Succinate dehydrogenase complex, subunit C, integral membrane protein, 15 kDa

− 4.59

F03

UQCR11

NM_006830

Ubiquinol-cytochrome c reductase, complex III subunit XI

− 4.87

F08

UQCRQ

NM_014402

Ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5 kDa

− 2.77

F09

ARRDC3

NM_020801

Arrestin domain containing 3

− 3.08

F10

ASB1

NM_001040445

Ankyrin repeat and SOCS box containing 1

− 6.03

F11

CYB561D1

NM_182580

Cytochrome b-561 domain containing 1

− 11.48

F12

DNAJB

NM_006145

DnaJ (Hsp40) homolog, subfamily B, member 1

2.15

G01

EDN1

NM_001955

Endothelin 1

2.14

G04

HSPA1B

NM_005346

Heat shock 70 kDa protein 1B

2.34

G06

MitoH1

r4_NC_012920

Polycistronic_H1_3

− 2.95