Table 2 The International Cartilage Repair Society II scoring system [24]
From: Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway
Histological parameter | Score (0–100) |
|---|---|
1. Tissue morphology | 0: Full thickness collagen fibers 100: Normal cartilage birefringence |
2. Matrix staining | 0: No staining 100: Full metachromasia |
3. Cell morphology | 0: No round/oval cells 100: Mostly round/oval cells |
4. Chondrocyte clustering | 0: Present 100: Absent |
5. Surface architecture | 0: Delamination or major irregularity 100: Smooth surface |
6. Basal integration | 0: No integration 100: Complete integration |
7. Formation of a tidemark | 0: No calcification front 100: Tidemark |
8. Subchondral bone abnormalities/marrow fibrosis | 0: Abnormal 100: Normal marrow |
9. Inflammation | 0: Present 100: Absent |
10. Abnormal calcification/ossification | 0: Present 100: Absent |
11. Vascularization (within the repaired tissue) | 0: Present 100: Absent |
12. Surface/superficial assessment | 0: Total loss or complete disruption 100: Resembles intact articular cartilage |
13. Mid/deep zone assessment | 0: Fibrous tissue 100: Normal hyaline cartilage |
14. Overall assessment | 0: Bad, fibrous tissue 100: Good, hyaline cartilage |