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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The stromal vascular fraction mitigates radiation-induced gastrointestinal syndrome in mice

Fig. 2

SVF treatment mitigating GIS. a Cell concentration-dependent effect of SVF on weight loss changes at 7 days of mice exposed to 18 Gy abdominal irradiation. b Weight loss changes for 30 days (n = 8) and c Kaplan-Meier survival analysis of 18 Gy abdominal exposed mice receiving SVF (2.5 × 106 cells) treatment, or not receiving treatment. The data are represented by mean ± SEM; p values were calculated by ANOVA with Bonferroni correction; *p < 0.05; **p < 0.01; ***p < 0.001 compared with the irradiated group. d Number of regenerative crypts at day 3.5 after 18 Gy abdominal irradiation with or without SVF (2.5 × 106 cells) treatment. e Representative immunostaining of Tunel and the number of Tunel+ cells in the ileal sections from the control in irradiated and irradiated SVF-treated mice 7 days post-irradiation. f Intestinal permeability checked by FITC/dextran assay in non-irradiated mice and 7 days after abdominal irradiation with or without SVF treatment. g Representative immunostaining of Zonulin-1 (ZO-1) in the ileal sections from the control in irradiated and irradiated SVF-treated mice 7 days post-irradiation. Scale bar 50 μm. The data are represented by mean ± SEM (n = 8). p values were calculated by ANOVA with Bonferroni correction; ***p < 0.001 compared with the control mice; ###p < 0.001 compared with the irradiated mice

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