Fig. 8
From: MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis
Proposed model that miR-375 suppresses the stemness of GC cells. SLC7A11 is selective for uptaking cystine into the cell in exchange for glutamate. This system synthesizes glutathione (GSH) by taking extracellular cystine into the cell and thus represses lipid peroxidation in ferroptosis; this process is suppressed by miR-375 which can directly target SLC7A11. Additionally, miR-375 has no effect on iron concentration