Fig. 5

Contribution of the SEZ in dopaminergic neurogenesis in the SNpc. A–D Characteristic images of DiI+/TH+ newborn dopaminergic neurons in the SNpc (indicated by white arrows), derived from the SEZ neurogenic niche of the adult brain [scale bar = 50 μm]. E Profile of DiI+ dopaminergic (TH+) neurons of the SNpc in wild-type (WT) and “weaver” (wv) mice, after BNN-20 [or saline (sal)] administration, based on co-expression of FoxA2 [n = 2 mice per group. Error bars are SEMs. Statistical analysis was performed using two-way ANOVA followed by Bonferroni post hoc test]. F Representative triple immunofluorescence image depicting a cluster of DiI+/TH+ neurons in a WT BNN-20 SNpc. The white arrow indicates a TH+/DiI+/FoxA2+ cell and the yellow arrow a TH+/DiI+/FoxA2− dopaminergic neuron [scale bar = 50 μm]