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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Selective ablation of cochlear hair cells promotes engraftment of human embryonic stem cell-derived progenitors in the mouse organ of Corti

Fig. 3

Immunohistological and cell count results of WT mice on day seven and day 14 after cell transplantation. A Schematic of the protocol of cell transplantation. B The graph shows the numbers of transplanted human cells in the organ of Corti and the spiral ganglion of the mouse cochlea at day 7 and day 14 after transplantation, n = 6 for day 7 and n = 4 for day 14. C The graph shows numbers of transplanted human cells in the scala tympani, scala vestibuli, and scala media of the mouse cochlea on day 7 and day 14 after transplantation, n = 6 for day 7 and n = 4 for day 14. D Immunohistochemistry of the cochleae at day 7, day 14 after cell transplantation. Green indicates Cell-EGFP, White indicates Sox2, yellow indicates neurofilament, and blue indicates DAPI. Red staining includes Myo7a, Phalloidin, and Sox2. Most of the transplanted cells are in the scala tympani. No cells were found in the organ of Corti, while a few cells migrated in the spiral ganglion. White arrows show the transplanted cells. Scale bars represent 100 μm. SM, scala media; ST, scala tymoani; RWM, round window membrane; SV, scala vestibule; WT, wild type

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Stem Cell Research & Therapy

ISSN: 1757-6512