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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6

Fig. 8

Downregulation of TSG-6 blocked the effect of MSCs-Exo in alleviating colitis. a Schematic diagram of the experimental design. b Survival rate of mice in the DSS + PBS and DSS + siTSG-6 Exo groups (n = 8 per group). Body weight (c) and DAI (d) were recorded daily during the experiment. Colonic macroscopic images (e), colon length (f), MPO (g), H&E staining, and histological score (h) in the DSS + PBS, DSS + siNC Exo, and DSS + siTSG-6 Exo groups at day 10. Data are presented as mean ± SD. *P < 0.05, **P < 0.01 and ns indicates P > 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512