Fig. 6

Transplantation of HUMSC-iHeps improve acute liver failure induced by concanavalin A. A Schematic diagram of encapsulated HUMSC-iHeps transplantation relieved mice with CoA-induced acute liver failure. B The Kaplan-Meier survival curves of CoA-induced acute liver failure mice that injected PBS, encapsulated HUMSC-iHeps, and PHHs. *P < 0.05, log rank test. C Serum levels of ALT, ALP, and AST in moribund control mice (n = 3), surviving HUMSC-iHeps-transplanted mice (n=3), and surviving PHHs-transplanted mice (n = 3). D Livers (up), macroscopic images of freshly isolated livers and liver sections (down), hematoxylin and eosin staining from Con-A-treated mice before (day 0), and after HUMSC-iHeps transplantation (days 4 and 7). Note Con-A-induced hepatitis and hemorrhage in the liver at day 0 (up) and arrows in (down), residual liver damage at day 4 (up) and arrowheads in (down), and the completely recovered liver at day 7