Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: High-efficiency c-Myc-mediated induction of functional hepatoblasts from the human umbilical cord mesenchymal stem cells

Fig. 7

Regulatory network altered by c-Myc at early stage of induction revealed by RNA-seq and ChIP-seq. A Volcano plot indicating differentially expressed genes in the c-Myc+3TFs group relative to 3TFs-induced HUMSCs after 6 days of induction. B Enriched gene sets and pathways in c-Myc+3TFs induced HUMSCs revealed by GSEA analysis. C Three genes with c-Myc binding sites in their promoters expressed differentially in the two groups. D Heatmap of the three genes’ expression in six samples. E c-Myc binding site information of the three genes detected from ChIP-seq. F Genome browser plot showing the c-Myc binding sites within promoter of the three genes, KLF4, UBD, and G6PD

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512