Fig. 3
From: Adipose-derived stem cells therapy effectively attenuates PM2.5-induced lung injury
ADSC transplantation affected the gene expression profile in PM2.5-exposed lungs. A The fold changes in the expression of differentially expressed genes (DEGs) in the control group vs PM2.5 group and the PM2.5 group vs PM2.5-ADSC group were visualized in a volcano plot. B The advanced bubble chart shows the top 6 significantly enriched KEGG pathways of the up- and downregulated DEGs in the control group vs PM2.5 group and the PM2.5 group vs PM2.5-ADSC group. C The gene expression profiles of the downregulated DEGs in the PM2.5 group vs PM2.5-ADSC group that were enriched in inflammatory pathways, as determined by KEGG pathway analysis, are shown in the heat map. D To verify the RNA-sequencing results, mRNA levels were measured by real-time qPCR. In A–C, N = 3; in D, N = 5; the data are presented as the mean ± SD; asterisk indicates p < 0.05; double asterisks indicate p < 0.01