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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Bone marrow-derived mesenchymal stem/stromal cells in patients with acute myeloid leukemia reveal transcriptome alterations and deficiency in cellular vitality

Fig. 1

AML-MSCs and HD-MSCs showed similarities in immunophenotyping and stemness. a Representative clinicopathologic sections of bone morrow from healthy donors (HD) and AML patients (AML), respectively. Scale bar=100 μm. b Bone marrow biopsy of hemocytes in HD and AML patients, respectively. Scale bar=20 μm. c Blood routine examination of peripheral blood (WBC, Hb, PLT) in HD and AML. d Representative morphogen of cultured bone marrow-derived MSCs (HD-MSCs, AML-MSCs). e, f Representative histogram (e) and statistical analysis (f) of biomarker expression in HD-MSCs and AML-MSCs by flow cytometry (FCM). Data were shown as mean ± SEM (n = 3). NS, not significant. g qRT-PCR analysis of stemness-associated (POU5F1, SOX2, NANOG) biomarkers in HD-MSCs and AML-MSCs (mean ± SEM, n = 4). NS, not significant. h Karyotypic analysis of AML-MSCs and HD-MSCs

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Stem Cell Research & Therapy

ISSN: 1757-6512