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Table 3 CT evaluation

From: Cell therapy in patients with COVID-19 using Wharton’s jelly mesenchymal stem cells: a phase 1 clinical trial

Parameters Patient- 1
(WJ-MSC treatment)
Patient- 2
(WJ-MSC treatment)
Patient- 3
(WJ-MSC treatment)
Patient- 4
(WJ-MSC treatment)
Patient- 5
(WJ-MSC treatment)
Base Day 14 Day 30 Base Day 14 Day 30 Base Day 14 Day 30 Base Day 14 Day 30 Base Day 14 Day 30
 • CT parenchymal abnormalities:                
  a- GG0 b a ,c a a,b,d,e a,c,d,e a, c a,c a,c,d a b a,b,e a,e a,b,d,g a,b,d NA
  b- Consolidation                
  c- Reticular pattern                
  d- Mixed pattern                
  e- Linear opacities                
  f- Multifocal GGO of rounded morphology                
  g- Reverse halo sign or other findings of organizing pneumonia                
 • Type of GGO opacities:                
  a- Pure GGO                
  b- Crazy paving: GGO + intralobular lines a a a d c,d d a a,d d a a,d a,d b a NA
  c- Irregular lines and interfaces with architectural distortion + GGO                
  d- Streaky pattern                
 • Zonal involvement:                
  a- Right upper: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) a (3) a (2) a (0) a (3) a (4) a (3) a (2) a (3) a (2) a (4) a (5) a (1) a (2) a (5) NA
  b- Right middle: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) b (3) b (2) b (0) b (4) b (2) b (2) b (2) b (3) b (1) b (4) b (5) b (2) b (3) b (5)  
  c- Right lower: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) c (3) c (1) c (0) c (4) c (2) c (2) c (2) c (3) c (2) c (4) c (3) c (2) c (3) c (5)  
  d- Left upper: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) d (3) d (2) d (1) d (3) d (4) d (3) d (2) d (3) d (2) d (4) d (5) d (1) d (3) d (5)  
  e- Left middle: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) e (3) e (1) e (0) e (4) e (2) e (2) e (2) e (3) e (1) e (4) e (5) e (2) e (4) e (5)  
  f- Left lower: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) f (3) f (2) f (1) f (4) f (3) f (2) f (3) f (3) f (2) f (4) f (3) f (2) f (3) f (5)  
 • Total score of zonal involvement in both lungs: 18 10 2 22 17 14 13 18 10 24 26 10 18 30 NA
 • Cardiomegaly: (Yes/No)
  Severity (mild, moderate, severe)
Yes (mild) Yes (mild) Yes (mild) Yes (mild) Yes (mild) Yes (mild) No No No Yes (mild) Yes (mild) Yes (mild) Yes (mild) Yes (mild) NA
  a. Highly suggested                
  b. Indeterminate a b d a b c a a b a b b a a NA
  c. Inconsistent                
  d. None