Skip to main content

Table 3 Rates of fistula closure and recurrence in patients in the anti-TNF and stem cell groups

From: Comparative perianal fistula closure rates following autologous adipose tissue-derived stem cell transplantation or treatment with anti-tumor necrosis factor agents after seton placement in patients with Crohn’s disease: a retrospective observational study

  Anti-TNF (n=39) Stem cell (n=30) P by log-rank test Unadjusted HR (95% CI) p-value Adjusted HR (95% CI) p-value
Cumulative fistula closure, n (%) 9 (23.1%) 25 (83.3%) <0.001 8.17 (3.72-17.94) <0.001 3.15 (1.22-8.13) 0.018
 1 year 4 (10.3%) 18 (60.0%)      
 2 year 6 (15.4%) 23 (76.7%)      
 3 year 9 (23.1%) 24 (80.0%)      
Closure time, mean±SD (months) 36.7±19.2 13.7±15.5    <.001   
Cumulative fistula recurrence, n (%) 0 (0%) 3 (10.0%) 0.288 2.64 (0.9-81.18) 0.578   
 1 year - 1 (33.3%)      
 2 year - 1 (33.3%)      
 3 year - 1 (33.3%)      
Recurrence time, mean±SD (months) - 21.33±13.05 -     
Follow up, mean±SD (months) 42.9±16.0 39.2±18.6    0.385   
  1. Results are presented as n (%) unless otherwise indicated.
  2. TNF tumor necrosis factor, SD Standard deviation