Fig. 2

hucMSC-derived exosomes alleviate DSS-induced mice colitis. a Colitis model established. The model contained the control (Neg), IBD, and hucMSC-Ex groups. 3% DSS was given at day 1 to mice in the IBD group and hucMSC-Ex group. Mice in the hucMSC-Ex group were given hucMSC-derived exosomes iv. at days 3, 6, and 9. b Fluorescence distribution of DIR-labeled hucMSC-derived exosomes in mouse colon after injection. c The mouse body weight loss. d DAI index of mice. e Mouse colon appearance. f H&E staining of mouse colon (200×, scale bar = 50 μm). g QRT-PCR analysis of the expression of inflammatory cytokines (IL-6, TNF-α, IL-10) in mouse colon tissues. #P < 0.05, ##P < 0.01, ###P < 0.001 vs Ctrl by ANOVA; *P < 0.05, **P < 0.01, ***P < 0.001 vs LPS + NIG by ANOVA