Table 1 General characteristics of preclinical studies investigating the efficacy of MSCÂ therapy in models of PF
From: Mesenchymal stem cell therapy in pulmonary fibrosis: a meta-analysis of preclinical studies
Author (year) | Country | Species, strain, gender | No. of treated animals | No. of controls | PF model | MSC source | MSC dose | MSC route | Transplant type | Time of MSC therapy after PF | Follow-up (days) |
|---|---|---|---|---|---|---|---|---|---|---|---|
Li et al. (2017) [43] | China | Mouse C57BL/6, M | 5 | 5 | Radiation | BMSC | 2.0 × 106 | iv | Allograft | 2 h | 42 d |
Xia et al. A (2015) [44] | China | Mouse, NR, NR | 25 | 25 | Radiation | BMSC | 1.0 × 103 | iv | Xenograft | 1 d | 28 d |
Xia et al. B (2015) | China | Mouse, NR, NR | 25 | 25 | Radiation | BMSC | 5.0 × 103 | iv | Xenograft | 1 d | 28 d |
Xia et al. C (2015) | China | Mouse, NR, NR | 25 | 25 | Radiation | BMSC | 1.0 × 104 | iv | Xenograft | 1 d | 28 d |
Guo et al. (2018) [23] | China | Tree shrews, NR, F | 20 | 20 | Radiation | UCMSC | 3.0 × 107 | iv | Allograft | 1 h, 7 d, 14 d, 21 d | 28 d |
F. Cahill et al. A (2016) [45] | Ireland | Mouse C57BL/6, F | 5 | 5 | BLM | BMSC | 5.0 × 104 | iv | Allograft | 6–8 h | 28 d |
F. Cahill et al. B (2016) | Ireland | Mouse C57BL/6, F | 5 | 5 | BLM | BMSC | 5.0 × 104 | iv | Allograft | 9 d | 28 d |
Zhang et al. (2018) [24] | China | Rat, SD, M | 6 | 6 | Silica | BMSC | 2.0 × 106 | iv | Allograft | 28 d | 28 d |
He et al. (2020) [19] | China | Rat, SD, M/F | 22 | 20 | PQ | AMSC | 2.0 × 106 | iv | Xenograft | 6 h | 21 d |
Moroncini et al. (2018) [46] | Italy | Mouse C57BL/6, F | 8 | 8 | BLM | UCMSC | 2.5 ×  105 | iv | Xenograft | 1 d, 7 d | 21 d |
Chen et al. (2019) [10] | China | Mouse C57BL/6, M | 10 | 10 | PQ | BMSC | 2.0 × 106 | iv | Allograft | 7 d | 14 d |
Tashiro et al. (2015) [47] | USA | Mouse C57BL/6, M | 5 | 12 | BLM | ADMSC | 5.0 × 105 | iv | Allograft | 1 d | 21 d |
Ai et al. (2019) [48] | China | Mouse C57BL/6, M | 10 | 10 | BLM | ADMSC | 5.0 × 106 | iv | Allograft | 1 d | 14 d |
Zhang et al. (2019) [20] | China | Rat, SD, M | 10 | 10 | PQ | BMSC | 3.0 × 106 | ip | Allograft | 1 h | 1 d |
M. Kumamoto et al. (2009) [49] | Japan | Mouse C57BL/6, F | 20 | 25 | BLM | BMSC | 5.0 × 106 | iv | Allograft | 3 d | 10 d |
Reddy et al. (2016) [50] | India | Mouse Swiss-albino, M | 10 | 10 | BLM | ADMSC | 4.0 × 107 | iv | Xenograft | 3 d, 6 d, 9 d | 21 d |
Rojas et al. (2005) [51] | USA | Mouse C57BL/6, NR | 5 | 6 | BLM | BMSC | 5.0 × 106 | iv | Allograft | 6 h | 14 d |
Wang et al. (2012) [40] | China | Mouse BALB/c, M | 6 | 6 | BLM | EMSC | 2.0 × 105 | iv | Xenograft | 1 d | 14 d |
Lee et al. (2014) [31] | Korea | Mouse C57BL/6, M | 10 | 20 | BLM | ADMSC | 3.0 × 105 | ip | Xenograft | 60 d | 60 d |
Chen et al. (2018) [52] | China | Rat, SD, M | 5 | 5 | Silica | ADMSC | 5.0 × 105 | iv | Allograft | 1 d | 28 d |
Lee et al. (2010) [53] | Korea | Rat, SD, F | 10 | 10 | BLM | BMSC | 1.0 × 107 | iv | Allograft | 4 d | 28 d |
Periera-simon et al. (2020) [21] | USA | Mouse C57BL/6, NR | 15 | 15 | BLM | ADMSC | 5.0 × 105 | iv | Xenograft | 1 d | 21 d |
Aguilar et al. (2009) [22] | UK | Mouse C57BL/6, M | 6 | 6 | BLM | BMSC | 5.0 × 106 (1 d, 3 d) | iv | Allograft | 8 h | 14 d |
Chen et al. (2020) [54] | China | Mouse C57BL/6, M | 5 | 5 | BLM | MenSC | 5.0 × 105 | iv | Xenograft | 2 d, 7 d | 21 d |
Lan et al. (2015) [38] | China | Mouse C57BL/6, F | 6 | 6 | BLM | BMSC | 5.0 × 105 | it | Allograft | 3 d | 21 d |
Yuben et al. (2009) [55] | Australia | Mouse, SCID, NR | 8 | 8 | BLM | UCMSC | 1.0 × 106 | iv | Xenograft | 1 d | 28 d |
Moodley et al. A (2013) [17] | Australia | Mouse C57BL/6, F | 8 | 8 | BLM | BMSC | 1.0 × 106 | iv | Xenograft | 3 d | 21 d |
Moodley et al. B (2013) | Australia | Mouse C57BL/6, F | 8 | 8 | BLM | AMSC | 1.0 × 106 | iv | Xenograft | 3 d | 21 d |