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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Pretreatment of cardiac progenitor cells with bradykinin attenuates H2O2-induced cell apoptosis and improves cardiac function in rats by regulating autophagy

Fig. 3

Autophagy participated in the BK-regulated apoptosis induced by H2O2 in hCPCs. A–B Representative image and quantitative analysis of TUNEL staining in hCPCs induced by H2O2 or rapamycin and treatment with BK or 3-MA. C Quantitative analysis of Annexin V flow cytometry assay in hCPCs induced by H2O2 or rapamycin and treatment with BK or 3-MA. D Apoptosis-related protein expression, including Bax, Bcl-2, cleaved caspase 3, induced with H2O2 or rapamycin, and treatment with BK or 3-MA. E Autophagy-related protein expression, including LC3II/I, Beclin 1, and P62, induced with H2O2 or rapamycin and treatment with BK or 3-MA. (Data are shown as mean ± SEM, n = 5, *P < 0.05, **P < 0.01 VS. control; #P < 0.05, ##P < 0.01 VS. H2O2; &P < 0.05, &&P < 0.01 VS. Rapa)

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Stem Cell Research & Therapy

ISSN: 1757-6512