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Table 3 The PEDI and CP-QoL mean difference within-groups (from baseline) and the difference between groups

From: Clinical and imaging outcomes after intrathecal injection of umbilical cord tissue mesenchymal stem cells in cerebral palsy: a randomized double-blind sham-controlled clinical trial

Outcomes

Test of within-group mean change from effects of baseline

Test of between-groups effects mean change control group

Control

MSC

MSC vs control

Mean [95% CI]

Mean [95% CI]

β

[95% CI]

P.v

Cohen’s d [95% CI]

PEDI self-care

 T3

1.89 [0.16, 3.62]

1.94 [0.39, 3.50]

−0.01

[−2.36, 2.35]

0.99

0.01 [−0.5, 0.56]

 T4

0.15 [−1.63, 1.95]

3.43 [1.79, 5.08]

3.22

[0.75, 5.69]

0.011

0.79 [0.22, 1.32]

PEDI mobility

 T3

0.13 [−1.69, 1.91]

1.63 [−0.62, 3.90]

1.53

[−1.38, 4.38]

0.29

0.33 [−017, 0.84]

 T4

0.81 [−1.09, 2.72]

3.88 [1.48, 6.27]

3.19

[0.16, 6.22]

0.039

0.62 [0.07, 1.17]

PEDI social function

 T3

3.04 [0.86, 5.23]

2.56 [1.01, 4.12]

−0.52

[−3.30, 2.25]

0.71

0.09 [−0.60, 0.42]

 T4

1.35 [−0.93, 3.60]

1.60 [−0.02, 3.23]

0.20

[−2.69, 3.09]

0.89

0.08 [−0.45, 0.62]

PEDI total

 T3

5.09 [1.35, 8.83]

6.08 [2.68, 9.47]

0.89

[−4.23, 6.02]

0.73

0.11 [−0.40, 0.62]

 T4

1.58 [−2.30, 5.46]

8.53 [4.98, 12.08]

6.87

[1.52, 12.21]

0.012

0.70 [0.14, 1.23]

CPQOL

Friends and family

 T3

−1.78 [−8.78, 5.20]

5.0 [−1.08, 11.09]

6.92

[−2.36, 16.22]

0.14

0.42 [−0.09, 0.93]

 T4

−10.36 [−17.45, −3.28]

0.92 [−5.33, 7.18]

11.23

[1.74, 20.71]

0.020

0.63 [0.1, 1.16]

Participate in activities

 T3

−2.20 [−4.84, 0.43]

1.02 [−1.28, 3.33]

3.21

[−0.30, 6.73]

0.074

0.45 [−0.06, 0.97]

 T4

−4.20 [−6.88, −1.53]

0.49 [−1.84, 2.87]

4.61

[1.01, 8.20]

0.012

0.65 [0.11, 1.19]

Communication

 T3

−2.65 [−4.42, −0.88]

−1.18 [−2.95, 0.59]

1.50

[−1.00, 4.00]

0.241

0.29 [−0.20, 0.78]

 T4

−1.99 [−3.83, −0.15]

0.56 [−1.29, 2.43]

2.54

[0-0.06, 5.16]

0.05

0.63 [0.1, 1.16]

Physical health

 T3

−1.27 [−6.78, 4.29]

6.85 [1.17, 12.52]

8.15

[0.25, 16.06]

0.043

0.58 [0.06, 1.10]

 T4

−3.54 [−9.12, 2.02]

2.0 [−3.82, 7.84]

5.34

[−2.71, 13.41]

0.19

0.40 [−0.12, 0.93]

Special equipment

 T3

−0.74 [−2.95, 1.42]

0.35 [−1.89, 2.59]

1.08

[−2.0, 4.21]

0.49

0.13 [−0.37, 0.64]

 T4

0.45 [−1.76, 2.67]

−1.32 [−3.63, 0.97]

−1.71

[−4.91, 1.48]

0.29

0.31 [−0.84, 0.21]

Pain and impact of disability

 T3

−0.86 [−6.33, 4.59]

3.41 [−0.76, 7.59]

4.42

[−2.11, 11.36]

0.21

0.25 [−0.26, 0.76]

 T4

1.31 [−4.22, 6.58]

3.52 [−0.77, 7.82]

0.70

[−4.55, 9.59]

0.48

0.16 [−0.36, 0.68]

Access to services

 T3

−6.09 [−11.43, −0.74]

−4.31 [−9.52, 0.89]

1.64

[−5.82, 9.11]

0.66

0.14 [−0.37, 0.65]

 T4

−8.66 [−14.08, −3.24]

−4.93 [−10.28, 0.42]

4.0

[−03.61, 11.62]

0.30

0.24 [−0.28, 0.77]

Family health

 T3

−3.28 [−6.21, −0.35]

0.39 [−1.86, 2.64]

3.66

[−0.5, 7.38]

0.054

0.49 [−0.02, 1.01]

 T4

−2.52 [−5.49, 0.44]

−1.09 [−3.40, 1.22]

1.29

[−2.49, 5.09]

0.503

0.21 [−0.31, 0.73]

CPQOL-total

 

 T3

−18.3 [−36.19, −0.37]

12.5 [−2.27, 27.23]

30.74

[−0.24, 0.57]

0.010

0.65 [0.13, 1.17]

 T4

−29.3 [−47.5, −11.2]

0.05 [−15.11, 15.22]

29.27

[5.50, 53.04]

0.016

0.68 [0.14, 1.22]