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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Bone marrow mesenchymal stem cells promote remyelination in spinal cord by driving oligodendrocyte progenitor cell differentiation via TNFα/RelB-Hes1 pathway: a rat model study of 2,5-hexanedione-induced neurotoxicity

Fig. 2

MBP expression and the number of OLs in the spinal cord of HD-exposed rats with or without BMSCs. a Representative images stained for NG2 (green, marker of OPCs) and MBP (red, marker of mature OLs). Scale bar, 50 μm. b Quantification of MBP+ and NG2+ cells. c Western blot results of MBP expression in the spinal cords of HD/BMSC-treated rats. d Representative phase images of cultured OPCs treated with HD/HD + BMSC-CM. Yellow arrows represent OPCs, cyan arrows represent immature OLs, and green arrows represent mature OLs. Scale bar, 50 μm. e Quantification of OPCs, immature OLs, mature OLs and death cell. f Western blot of MBP in HD/BMSC-treated OLs. Quantified data are shown as mean ± SD. a: Compared with control group, p < 0.05; b: compared with HD group, p < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512