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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Bone marrow mesenchymal stem cells promote remyelination in spinal cord by driving oligodendrocyte progenitor cell differentiation via TNFα/RelB-Hes1 pathway: a rat model study of 2,5-hexanedione-induced neurotoxicity

Fig. 4

Expression of Jagged1, Notch1, NICD and RBPJ in the spinal cord of HD-treated rats and HD-treated OPCs with or without BMSCs/BMSC-CM. a–d qRT-PCR results showing Jagged1, Notch1, NICD and RBPJ mRNA expression in the spinal cords of HD/BMSC-treated rats. e Western blot results showing Jagged1, Notch1, NICD and RBPJ protein expression in the spinal cords of HD/BMSCs-treated rats. f–i qRT-PCR results of Jagged1, Notch1, NICD and RBPJ in HD/BMSC-CM-treated OPCs. j Western blot results of Jagged1, Notch1, NICD and RBPJ in HD/BMSC-CM-treated OPCs. Bar graph present mean ± SD. a: Compared with control group, p < 0.05; b: compared with HD group, p < 0.05; c: compared with HD + BMSCs/BMSC-CM group, p < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512