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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Melatonin contributes to the hypertrophic differentiation of mesenchymal stem cell-derived chondrocytes via activation of the Wnt/β-catenin signaling pathway

Fig. 5

Melatonin activates Wnt-target genes during hypertrophic differentiation of BMSC-derived chondrocytes. a qRT-PCR array results in MSC-derived chondrocytes with or without 100 nM melatonin treatment for 1, 3, and 5 days without hypertrophic inducement. b The expression of downstream genes of the Wnt/β-catenin signaling pathway in MSC-derived chondrocytes during hypertrophic differentiation with or without 100 nM melatonin treatment for 1 day, 3 days, and 5 days. c The mRNA expression of TCF1 in the MSC-derived chondrocytes during hypertrophic differentiation. Gene expression levels were normalized to GAPDH mRNA. d The protein expression of TCF1/TCF7 in MSC-derived chondrocytes. *P < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512