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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: HDAC6 inactivates Runx2 promoter to block osteogenesis of bone marrow stromal cells in age-related bone loss of mice

Fig. 1

Age-related bone loss in mice. Femur (A), tibia (C) and L5 vertebrae (E) were harvested from 6- (Young) and 18-month-old (Aged) mice. Micro-CT was employed to evaluate the trabecular bone microstructure. Trabecular bone parameters including BV/TV, Tb.N, and Tb.Sp were quantified according to Micro-CT scans. Representative 3D reconstruction images of trabecular bone in the distal femur (B), proximal tibia (D), and L5 vertebrae (F) were displayed. Serum levels of bone turnover markers, osteocalcin and N-telopeptide, in young and aged mice were determined by ELISA (G). Data were shown as the means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, aged versus young

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Stem Cell Research & Therapy

ISSN: 1757-6512