Fig. 5
From: Targeted gene correction and functional recovery in achondroplasia patient-derived iPSCs
Chondrogenic differentiation of corrected ACH iPSCs. a The number of chondrogenic clusters from corrected iPSCs obviously increased compared with that from uncorrected cells. Bar: 100 μm. b Safranin O staining illustrated that cartilage tissues from corrected ACH iPSCs demonstrated more positive areas than those from uncorrected cells. Bar: 10 μm. c RT-qPCR results also revealed that the expression level of chondrocyte-specific genes—SOX9, COL2A1, and ACAN from corrected ACH iPSCs were higher than those of ACH iPSCs