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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: The effect of genetically modified platelet-derived growth factor-BB over-expressing mesenchymal stromal cells during core decompression for steroid-associated osteonecrosis of the femoral head in rabbits

Fig. 6

Assessment of osteonecrotic lesions. H&E staining was performed to evaluate the extent of osteonecrotic lesions within the femoral head. a Representative images of each treatment group are shown. Empty lacunae and pyknotic cells were observed in all treatment groups. Additionally, degenerative changes of the bone marrow such as granulation tissue were observed, indicating that osteonecrosis had taken place in all groups. b Within the subchondral bone and in the bone surrounding the bone tunnel area, the PGK-PDGF-BB-MSC group demonstrated a significantly lower percentage of empty lacunae than the other treatment groups (P < 0.001 for all). Scale bar: 100 µm. H&E, hematoxylin and eosin; CD core decompression, HG hydrogel, MSC mesenchymal stromal cell, PGK-PDGF-BB-MSC genetically modified phosphoglycerate kinase promoter platelet-derived growth factor-BB over-expressing MSC. ***P < 0.001, ****P < 0.0001

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Stem Cell Research & Therapy

ISSN: 1757-6512