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Table 1 Results of the evaluation of osteonecrosis

From: The effect of genetically modified platelet-derived growth factor-BB over-expressing mesenchymal stromal cells during core decompression for steroid-associated osteonecrosis of the femoral head in rabbits

Average percentage (%) of empty lacunae by position in femoral head (SD)
  Subchondral bone
1 2 3 4 Total P value
 CD 41.4 (28.7) 51.2 (22.6) 65.8 (16.7) 35.6 (19.2) 48.5 (23.8)  < 0.001
 HG 46.6 (22.6) 65.8 (19.9) 50.9 (20.9) 28.8 (20.3) 48.0 (23.7)  < 0.001
 MSC 58.9 (31.7) 71.6 (16.7) 40.7 (34.2) 8.8 (3.1) 45.0 (33.4)  < 0.001
 PGK-PDGF-BB-MSC 16.1 (15.7) 12.0 (9.9) 19.1 (12.5) 23.0 (22.2) 17.5 (15.3) 1.0
  Surrounding tunnel
5 6 7 Total P value
 CD 59.8 (23.1) 52.8 (22.1) 46.2 (11.5) 52.9 (19.3)  < 0.0001
 HG 64.2 (22.8) 44.9 (24.9) 27.1 (13.2) 45.4 (25.1)  < 0.001
 MSC 72.6 (13.4) 55.7 (21.9) 50.4 (25.7) 59.6 (21.9)  < 0.0001
 PGK-PDGF-BB-MSC 30.3 (20.7) 24.4 (17.6) 14.0 (7.8) 22.9 (16.8) 1.0
  1. The average percentage of empty lacunae for each position in the femoral head as described in Fig. 1 was calculated for each treatment group. The average percentage of empty lacunae for each region in the femoral head was calculated for each treatment group. A mixed effects model, where treatment group and femoral head position served as fixed effects, was used to perform the statistical analysis. The P values shown correspond to comparisons with the PGK-PDGF-BB-MSC treatment group. Comparisons between all other treatment groups did not reach statistical significance. SD standard deviation, CD core decompression, HG hydrogel, MSC mesenchymal stromal cell, PGK-PDGF-BB-MSC genetically modified phosphoglycerate kinase promoter platelet-derived growth factor-BB over-expressing MSC