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Table 1 Results of the evaluation of osteonecrosis

From: The effect of genetically modified platelet-derived growth factor-BB over-expressing mesenchymal stromal cells during core decompression for steroid-associated osteonecrosis of the femoral head in rabbits

Average percentage (%) of empty lacunae by position in femoral head (SD)

 

Subchondral bone

1

2

3

4

Total

P value

 CD

41.4 (28.7)

51.2 (22.6)

65.8 (16.7)

35.6 (19.2)

48.5 (23.8)

 < 0.001

 HG

46.6 (22.6)

65.8 (19.9)

50.9 (20.9)

28.8 (20.3)

48.0 (23.7)

 < 0.001

 MSC

58.9 (31.7)

71.6 (16.7)

40.7 (34.2)

8.8 (3.1)

45.0 (33.4)

 < 0.001

 PGK-PDGF-BB-MSC

16.1 (15.7)

12.0 (9.9)

19.1 (12.5)

23.0 (22.2)

17.5 (15.3)

1.0

 

Surrounding tunnel

5

6

7

Total

P value

 CD

59.8 (23.1)

52.8 (22.1)

46.2 (11.5)

52.9 (19.3)

 < 0.0001

 HG

64.2 (22.8)

44.9 (24.9)

27.1 (13.2)

45.4 (25.1)

 < 0.001

 MSC

72.6 (13.4)

55.7 (21.9)

50.4 (25.7)

59.6 (21.9)

 < 0.0001

 PGK-PDGF-BB-MSC

30.3 (20.7)

24.4 (17.6)

14.0 (7.8)

22.9 (16.8)

1.0

  1. The average percentage of empty lacunae for each position in the femoral head as described in Fig. 1 was calculated for each treatment group. The average percentage of empty lacunae for each region in the femoral head was calculated for each treatment group. A mixed effects model, where treatment group and femoral head position served as fixed effects, was used to perform the statistical analysis. The P values shown correspond to comparisons with the PGK-PDGF-BB-MSC treatment group. Comparisons between all other treatment groups did not reach statistical significance. SD standard deviation, CD core decompression, HG hydrogel, MSC mesenchymal stromal cell, PGK-PDGF-BB-MSC genetically modified phosphoglycerate kinase promoter platelet-derived growth factor-BB over-expressing MSC
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Stem Cell Research & Therapy

ISSN: 1757-6512