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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathway

Fig. 3

Establishment of SERPINB2 knockdown hBMSCs cell line and effects of SERPINB2 knockdown on osteogenic differentiation of hBMSCs. a–c Verification of SERPINB2 knockdown in hBMSCs. d SERPINB2 knockdown didn’t influence hBMSCs proliferation. e SERPINB2 knockdown significantly promoted the mRNA expression of COL1A1, RUNX2, SP7, OPN and OCN during osteogenesis differentiation at day 3. f, g SERPINB2 knockdown significantly promoted the protein expression level of COL1A1, RUNX2 and SP7 during osteogenesis differentiation at days 3 and 5. Data are expressed as mean ± SD. Assays were performed in triplicates. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 compared with the control group

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Stem Cell Research & Therapy

ISSN: 1757-6512