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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Additional benefit of induced pluripotent stem cell-derived mesenchymal stem cell therapy on sepsis syndrome-associated acute kidney injury in rat treated with antibiotic

Fig. 5

Glomerular ultrastructural expressions by day 5 after SS-AKIR procedure. A–F Illustrating immunofluorescent (IF) microscopic finding (400x) for identification of positively-stained zonula occludens-1 (ZO-1) in renal glomerulus (green color). G) Analytical result of ZO-1 expression. H–M Illustrating IF microscopic finding (400x) for identification of synaptopodin in renal glomerulus (green color). N Analytical results of synaptopodin expression. n = 6 for each group). * indicates p value  < 0.05; ** indicates p value  < 0.01; *** indicates p value  < 0.001; **** indicates p value  < 0.0001. G1 = (sham-operated control); G2 = sepsis syndrome (SS) + acute kidney ischemia–reperfusion (AKIR); G3 (SS + AKIR + ciprofloxacin administered at 3 h after SS-AKIR induction); G4 [SS + AKIR + iPS-MSCs by intravenous injection at 3 h, after SS-AKIR (i.e., defined as early treatment)]; G5 [SS + AKIR + iPS-MSCs by intravenous injection at 18 h after SS-AKIR (i.e., defined as late treatment) after SS-AKIR induction]; G6 [SS + AKIR + ciprofloxacin and iPS-MSCs at 3 h after SS-AKIR induction]. iPS-MSCs = induced pluripotent stem cells-derived mesenchymal stem cells

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Stem Cell Research & Therapy

ISSN: 1757-6512