Fig. 6

Kidney injury biomarker and podocyte component expressed in glomerulus by day 5 after SS-AKIR procedure. A–F Showing the immunofluorescent microscopic finding (200x) for identification of kidney injury molecule (KIM)-1 in renal tubules (green color). G Analytical results of KIM-1 expression. Scale bars in right lower corner represent 50 µm. H–M Illustrating the microscopic finding (200x) of immunohistochemical staining for identification of p-cadherin in glomeruli (gray color). N Analytical result of p-cadherin expression. Scale bars in right lower corner represent 20 µm. n = 6 for each group). * indicates p value  < 0.05; ** indicates p value  < 0.01; *** indicates p value  < 0.001; **** indicates p value  < 0.0001. G1 = (sham-operated control); G2 = sepsis syndrome (SS) + acute kidney ischemia–reperfusion (AKIR); G3 (SS + AKIR + ciprofloxacin administered at 3 h after SS-AKIR induction); G4 [SS + AKIR + iPS-MSCs by intravenous injection at 3 h, after SS-AKIR (i.e., defined as early treatment)]; G5 [SS + AKIR + iPS-MSCs by intravenous injection at 18 h after SS-AKIR (i.e., defined as late treatment) after SS-AKIR induction]; G6 [SS + AKIR + ciprofloxacin and iPS-MSCs at 3 h after SS-AKIR induction]. iPS-MSCs = induced pluripotent stem cells-derived mesenchymal stem cells