Table 3 Clinical trials of mesenchymal stem cell therapy in human allergic disease
| Â | Graft type | MSC source | Study type | Route | Dose | N | Frequency | Interval | Response | Side effects |
|---|---|---|---|---|---|---|---|---|---|---|
AD [157] | Allograft | Umbilical cord blood | Phase 1 | SQ | 2.5 × 107 (Low dose) | 3 | Single dose |  | Favourable | No severe side effects |
|  |  |  |  |  | 5 × 107 (High dose) | 3 |  |  |  |  |
|  |  |  | Phase 2a | SQ | 2.5 × 107 (Low dose) | 14 |  |  |  |  |
|  |  |  |  |  | 5 × 107 (High dose) | 11 |  |  |  |  |
CSU [159] | Autograft | Adipose tissue | Clinical study | IV | 1 × 106/kg (about 6 × 107 for 60 kg) | Treated 10 Control 10 | 2 times | 2 weeks | Favourable | None |