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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Transplantation of mesenchymal stem cells ameliorates systemic lupus erythematosus and upregulates B10 cells through TGF-β1

Fig. 5

TGF-β1 downregulation weakened the therapeutic effect of MSC transplantation in MRL/lpr mice. Spleen index (a), serum anti-dsDNA antibodies (b), 24 h urinary protein (c) of MRL/lpr mice treated with MSCs-shRNA-TGF-β1 transplant. d Representative images of glomerular capillary cell proliferation and renal interstitial inflammatory cell infiltration of MRL/lpr mice treated with MSCs-shRNA-TGF-β1 transplant; “*” represents interstitial inflammatory cell infiltration, the arrow “ → ” indicates vessels, and “$” means mesangial and cell proliferation. The scores of glomerular pathologies (e) and interstitial inflammation scores (f) of MRL/lpr mice treated with MSCs-shRNA-TGF-β1 transplant. Data are mean ± SD. MSCs-shRNA-Con (n = 7), MSCs-shRNA-TGF-β1 (n = 7). *p < 0.05, **p < 0.01. MSCs-shRNA-Con, MSCs infected by control lentivirus; MSCs-shRNA-TGF-β1, MSCs infected by lentivirus with TGF-β1 shRNA

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Stem Cell Research & Therapy

ISSN: 1757-6512