Fig. 3
From: CAR-T cell therapy in T-cell malignancies: Is success a low-hanging fruit?
Potential strategies for overcoming the issue of prolonged CAR-T persistence which leads to T-cell aplasia. A Selective elimination of the administered CAR-Ts that is achievable through equipping the CAR-Ts with different safety switches. B Transient CAR expression that can be achieved through the mRNA electroporation of the isolated T cells. CAR chimeric antigen receptor; FcÎłR FcÎł receptor; G ganciclovir; G-Mp ganciclovir-monophosphate; G-Tp ganciclovir-triphosphate; HSV-TK Herpes simplex virus thymidine kinase; iCasp inducible caspase; mAb monoclonal antibody