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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis

Fig. 9

Possible mechanism through which sTNFRII-MSC exert better therapeutic efficiency in alleviating the development and severity of CIA in mice. sTNFRII-Fc modification protects MSCs against apoptosis, autophagy and immunogenicity induced by inflammatory environment (TNF-α), in addition to releasing sTNFRII-Fc neutralizing TNF-α to block relevant immune-inflammation cascade

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Stem Cell Research & Therapy

ISSN: 1757-6512