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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations

Fig. 6

Results from Luminex are shown in a Z-score heatmap. Higher Z-score (orange) indicates positive regulation, and lower Z-score (blue) indicates negative regulation of secreted protein by MSCs. A Multiplex analysis of cytokines, chemokines and growth factors in the secretome of BM-MSCs in the THP-1 macrophage activation assay. B TNF-α suppression data for BM-MSC. One-way ANOVA with multiple comparisons (Tukey) test. THP-1 M is significant from all donors. BM1 (BM-High a cluster) is significant from BM4 (BM-High b cluster) and not from BM2a (BM-High a cluster). BM4 is significant from BM2a. These are standard error of the means. C Clusters of BM-MSC transcriptome profiles

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Stem Cell Research & Therapy

ISSN: 1757-6512