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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: PPARβ/δ accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy

Fig. 4

RNA sequencing shows PPARβ/δ agonist promotes the up-regulation of autophagy and osteogenic pathways in high-glucose environment. A The volcano plot shows that 684 genes up-regulated and 420 genes down-regulated in H5 group compared with H0 group. B KEGG enrichment analysis shows the signaling pathways up-regulated after GW501516 treatment. C KEGG network diagram shows the interaction between the up-regulated signal pathways after GW501516 treatment. D Heatmap of representative osteogenesis associated genes intensively expressed in H5 group compared with H0 group. E Heatmap of representative autophagy associated genes intensively expressed in H5 group compared with H0 group. F GSEA showed increased enrichment of osteogenic differentiation and autophagy-related regulatory genes after GW501516 treatment

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Stem Cell Research & Therapy

ISSN: 1757-6512