Mesenchymal stem cells-derived exosomes for drug delivery

Table 4 Delivery of protein by MSC-EXOs

Aim	Exosomes origin	Loading methods	Administration route	Model	Protein	References
Ameliorate cerebral ischemia–reperfusion injury	ADSCs	Overexpression	Local injection	Mice	PEDF	[42]
Improve cardiac regeneration	HucMSCs	Transfection	Intravenous injection	Mice	Akt	[121]
Anti-tumor	MSC	Electroporation	In vitro cell experiment	N/A	TNF-α	[123]
Anti-tumor	BMSCs	Transfection	Intravenous injection	Mice	TRAIL①	[126]
Cystic fibrosis	BMSCs	Transfection	In vitro cell experiment	N/A	Zinc Finger Protein	[128]
Prevent cisplatin injury	HucMSC	Transfection	In vitro cell experiment	N/A	14–3-3protein	[125, 127]
Enhance angiogenesis	HucMSCs	Overexpression	Subcutaneous injection	Mice	Angiopoietin-2	[122]

N/A, not applicable. ①TRAIL, tumor necrosis factor-related apoptosis-inducing ligand

ISSN: 1757-6512