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Table 4 Delivery of protein by MSC-EXOs

From: Mesenchymal stem cells-derived exosomes for drug delivery

Aim Exosomes origin Loading methods Administration route Model Protein References
Ameliorate cerebral ischemia–reperfusion injury ADSCs Overexpression Local injection Mice PEDF [42]
Improve cardiac regeneration HucMSCs Transfection Intravenous injection Mice Akt [121]
Anti-tumor MSC Electroporation In vitro cell experiment N/A TNF-α [123]
Anti-tumor BMSCs Transfection Intravenous injection Mice TRAIL [126]
Cystic fibrosis BMSCs Transfection In vitro cell experiment N/A Zinc Finger Protein [128]
Prevent cisplatin injury HucMSC Transfection In vitro cell experiment N/A 14–3-3protein [125, 127]
Enhance angiogenesis HucMSCs Overexpression Subcutaneous injection Mice Angiopoietin-2 [122]
  1. N/A, not applicable. TRAIL, tumor necrosis factor-related apoptosis-inducing ligand