Fig. 7

SCF and CXCL12 level determination in Casepase-3^−/− BA-MSCs after stimulated with LPS. A Western blot analysis of the expression of Caspase-3, NLRP3, Caspase-1, IL-1β, and GSDMD in WT BA-MSCs (WT), Caspase-3^−/− BA-MSCs (KO) and Caspase-3^−/− BA-MSCs stimulated with LPS for 72 h (KO + LPS) (n = 3). B ELISA analysis in the supernatants of WT BA-MSCs (WT), Caspase-3^−/− BA-MSCs (KO) and Caspase-3^−/− BA-MSCs stimulated with LPS for 72 h (KO + LPS) (n = 3–4). C The schematic summaries our findings that Caspase-3 might regulate SCF and CXCL12 levels via NLRP3 in BA-MSCs. All data are presented as mean ± SEM. ns: not significant, *P < 0.05, **P < 0.01