Fig. 2

Schematic representation of the features observed in cytokine-induced memory-like (CIML) NK cells. Key CIML NK cell features include increased expression of CD25 (IL-2Ra), decreased expression of KIRs, and TGFβ receptors which may help unleash the inhibition in CIML NK cells. Increased IFNγ production may contribute to the enhanced anti-tumor responses. Epigenetic changes like CpG demethylation have been reported, and others need further investigation. Metabolic changes in CIML NK cells including glucose transporter and transferrin receptor play an important role in the long-term persistence and recall functions