Fig. 1

Increased bone loss in Pink1^−/− mice after ovariectomy (OVX). The following parameters were calculated during the analysis of trabecular bone and architecture: a bone volume per total volume (BV/TV), b trabecular number (Tb.N), c trabecular thickness (Tb.Th), and d trabecular spacing (Tb.Sp). e Representative images of μCT and finite element analysis of femoral trabecular bones. Representative photographs of f hematoxylin–eosin (H&E), g Masson’s trichrome (MT), and h immunohistochemical staining of osteocalcin in femurs from WT or Pink1^–/– mice after OVX or sham operation. Data have been expressed as mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001; n = 6; scale bar = 50 μm