Fig. 4

BMSCs rescue the abnormal calcium activity of steatotic cells. A Representative Ca²⁺ transients induced by FCCP form linescan images recorded from isolated mHCs of ND (red), HFD (blue), and HFD-BMSCs (green) mice. B Representative Ca²⁺ transients induced by ATP form linescan images recorded from HepG2-GCAMP^mito cells treated with complete medium (red), FFA medium (blue), and FFA medium combined with BMSCs (green). C The detection of IP3R expression in the liver of ND, HFD, and HFD-BMSCs mice. The relative expression was determined by densitometry and normalized to β-actin levels. All trials above were performed with three independent replicates, and the statistical data are represented as means ± s. *P < 0.05; **P < 0.01; ***P < 0.001