Fig. 4
From: Co-administration of human MSC overexpressing HIF-1α increases human CD34+ cell engraftment in vivo
Schematic representation of the potential mechanisms by which HIF-1α overexpression in MSC could enhance CD34+ cell engraftment. HIF-1α action may depend more on secreted soluble factors than on cell-to-cell contact. Interaction through ligands and receptors, cytokine release and extracellular vesicle release contribute to this process. Molecules that are increased in HIF-MSC are represented in green and molecules that are decreased are represented in red. HSC, hematopoietic stem cell; CXCR4, C-X-C chemokine receptor type 4; ITGA4, integrin subunit alpha 4; SDF-1, stromal-derived factor-1; SCF, stem cell factor; EPO, erythropoietin; PDGF, platelet-derived growth factor; ANGPT, angiopoietin; VEGF, vascular endothelial growth factor; ROS, reactive oxygen species; EV, extracellular vesicles; MSC WT: MSC wild type; HIF-MSC: MSC overexpressing HIF-1α