Skip to main content

Table 1 Context-dependent transcriptional regulations of YAP/TAZ in stem cell and differentiation

From: Context-dependent transcriptional regulations of YAP/TAZ in stem cell and differentiation

System Interacting partners Context Regulated target genes Tissue/cell types Functions Main reference
Blastocyst TEAD Embryo development Cdx2 ESCs and embryos To distinguish the TE and ICM [45]
Oct4 and Nanog ICM To induce the epiblast lineage cells [47]
ESCs TEAD and P300 ESC differentiation Mcl1, Bcl2 and Bcl2l1 Mouse ESCs To promote cell survival during ESC differentiation [48]
TEAD and P73 RASSF1A-induced stem cell differentiation OCT4 and differentiation-associated genes Mouse ESCs Function as a “switch” between pluripotency and initiation of differentiation [49]
TEAD, SMAD2/3, OCT4, NuRD and FOXH1 TGF-β signalling-mediated ESC pluripotency maintenance and mesoderm specification NANOG and: EOMES Human ESCs To direct discrete SMAD2/3 signalling outcomes in the context of pluripotency and mesoderm induction [50]
NSCs TEAD and SMAD1/4 BMP2 activation in mouse embryonic NSCs Ccnd1 Mouse embryonic NSCs To represses the proliferation of embryonic NSCs [53]
SMAD1/5 Radial glia cell self-amplification in the developing cerebral cortex Radial glia cells To promote the radial glia cell self-amplification in embryos, and prevent their premature [54]
SMAD1/4/8 BMP2-induced neocortical astrocytic differentiation Astrocytic differentiation-associated genes NSCs and astrocytes To induce the astrocytic differentiation in the developing mouse neocortex [55]
Pax3 Neural crest development Mitf and Myf5 Premigratory neural crest cells Essential for neural crest delamination during embryonic development [56]
TEAD and SOX10 Schwann cell proliferation and myelination Gnas and myelination genes Peripheral nerves system and Schwann cells To promote Schwann cell proliferation and myelination [57]
MSCs and SSCs RUNX2 Src activation-mediated osteogenic differentiation Bone-specific osteocalcin gene Osteoblasts To repress osteoblast differentiation [60]
AP2a and RUNX2 Osteogenic differentiation and bone regeneration BARX1 MSCs Inhibition of osteoblast differentiation [61]
TEAD and RUNX2 Osteoblast differentiation and bone development Alp, Cola1, and Osterix MSCs and osteoblasts progenitor Inhibition of osteoblast differentiation [62]
TEAD and Snail/Slug SSCs differentiation Ctgf, Ankrd1, Axl, Dkk1 and Cyr61; Bglap2, Osterix and Alp SSCs To regulate SSC proliferation and osteogenic differentiation [64, 65]
Cardiac cells β-Catenin Hippo-deficient embryo hearts Sox2 and Snail2 Embryonic cardiomyocyte To regulate cardiomyocyte proliferation and heart size [68]
Myb-MuvB (MMB) complex Loss of the Hippo-signalling component SAV1 TOP2A, CDC20, CENPF and AURKA Embryonic cardiomyocyte To promote cardiomyocyte mitosis and proliferation [69, 70]
FoxO1 Oxidative stress response Catalase and MnSOD Cardiomyocytes To promote cell survival in response to oxidative stress [72]
TFEB Lysosomal storage diseases MAPLC3B LSD mouse model To promote autophagic and lysosomal gene expression [74]
ISCs TEAD and Klf4 In the intestinal epithelium expansion and differentiation Muc2, Rps26 Mouse intestine To regulate ISC proliferation and differentiation to goblet cells [76]
TLE Dual inhibition of TEAD-mediated transcriptional and LATS activities in ISCs Axin2 and Lgr5 ISCs To block Wnt/TCF-mediated transcription in ISCs [78]
Pancreas TEAD and Pancreatic-TFs Pancreas development SOX9, HHEX and MNX1 Human embryonic pancreas and ESC-derived progenitors To promote the outgrowth of pancreatic multipotent progenitor cells [79]
Liver TEAD and PPARα Liver growth and regeneration CTGF, CYR61, ANKRD1; AXOX1 and CYP4A Mouse live and hepatocyte To promote liver growth and regeneration [81]