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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Normal ex vivo mesenchymal stem cell function combined with abnormal immune profiles sets the stage for informative cell therapy trials in idiopathic pulmonary fibrosis patients

Fig. 6

Immnunoprofile comparison of blood samples from IPF patients and HCs using unpaired Student's t test. A. B cells panel. There is no difference in total B cell numbers between the tested groups. IPF patients have decreased percentage as well as cell number of [IgD + IgM +] cells, smaller percentage of transitional B cells, while higher percentage of [IgD-IgM-] cells. B. Granulocytes, eosinophils and neutrophils panel. IPF patients have elevated numbers of granulocytes, eosinophils as well as neutrophils than HCs. C. T cells panel: Total number of T (CD3 +) cells is not different between two groups, while the percentages of [CD4 + CTLA4 +], CD4 + CTLA4 + CD28 +], [C8 + CTLA4 +], [C8 + CTLA4 + CD28 +], [CD8 + PD-1 +] cells as well as [CD25 + Treg] and [CD4 + Tcm] T cells are elevated. Only the percentage CD25 + CD45RA + Treg cells is decreased. D. Monocytes panel: The monocyte phenotype showed higher percentage in IPF patients. Dots represent each individual values. *p < 0.05, **p < 0.01, ***p < 0.001, ***p < 0.0001, compared with control group

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Stem Cell Research & Therapy

ISSN: 1757-6512