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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Fig. 5

Osteogenic differentiation and proliferation of Grk3-/- BmMSCs are decreased to WT levels with sphingosine kinase inhibitor treatment. (A) BmMSCs treated with 5 µM SKI while in osteogenic media for differentiation studies and stained with Alizarin Red. Representative images acquired at 2X magnification, n = 3, 13, 14. (B) BmMSCs cultured with 5 µM SKI in culture media for proliferation detection over time. Data represent mean ± SEM, n = 3, passage 11 **P ≤ 0.01 ****P ≤ 0.0001

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Stem Cell Research & Therapy

ISSN: 1757-6512