Fig. 2
From: Single-cell RNA sequencing to track novel perspectives in HSC heterogeneity
Hierarchical models of hematopoiesis. A Representation of one of the classical views of hematopoietic hierarchical tree, showing hematopoietic cells of different potency. The top HSC pool incorporates highly heterogeneous progenitor populations with self-renewal and multipotent differentiation properties, downstream of which the first binary branch point separates the myeloid and lymphoid lineages. Oligopotent cells in the middle and terminally subdivide into different unipotent cells at the bottom by discrete differentiation stages [16, 41]. B HSC commitment schematic proposed by single-cell transcriptomic snapshots. The megakaryocytic-biased HSC shows a skewed direct production of Mk while retaining multi-lineage potential. The balanced HSC has equivalent contribution toward the production of all mature blood cells [42, 46]