From: Abnormal respiratory progenitors in fibrotic lung injury
Strain | Lineage | Markers |
---|---|---|
endodermal epithelial marker | Scgb1a1+ club epithelial cells in the proximal airway, with scattered expression in ciliated epithelium and Sftpc+ alveolar type II epithelial cells [82] | |
distal airway epithelial cells | Sox9 lineage cells can give rise to ATI and ATII cells after E13.5 | |
proximal airway lung epithelial cells | the majority of Sox2 lineage alveolar cells exhibited ATII marker Sftpc expression; Sox2 lineage labeled airway epithelial cells are basal, secretory, and ciliated epithelial cells in the airway of adult lung, but not alveolar cells [44] | |
Nkx2.1CreER [71] | both distal alveolar and proximal airway epithelial cells | Nkx2.1 lineage labeled cells were strictly epithelial cells, which co-stained with pan-epithelial marker EPCAM [85] |
Upk3aCreER [17] | lineage labeled cells are progenitors that give rise to club cells and ciliated cells in the postnatal period | Adult Upk3a lineage labeled cells were distributed in the airway, clustered around neuroepithelial bodies (NEBs) and located close to BADJs |
Igfbp2CreER [9] | ATI cells after postnatal day 1 (p1) | In this study, 95% of the Hopx+ ATI cells express Igfbp2 at p60. Hopx+Igfbp2+ cells are proposed to represent terminal differentiated populations of ATI cells |
lineage label BASCs | Tamoxifen exposure will enable recombination of Dre and Cre, which results in labeling of Sftpc+/Scgb1a1+ BASCs. Dre and Cre mouse lines were used by cross with R26-RSR-LSL-tdTomato [6], R26-comfetti2 [86], and R26-TLR [7] reporter mouse lines |