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Fig. 14 | Stem Cell Research & Therapy

Fig. 14

From: Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects

Fig. 14

Immunohistochemistry staining was employed to detect the expression of RUNX2 in the bone defect area. The black arrowheads indicate RUNX2-positive osteoblasts at the MBCP–new bone interface. The red arrows indicate a high expression region and RUNX2-positive osteocytes embedded within the bone and connective tissue matrix. Scale bar = 100 μm. (NB new bone, CT connective tissue, BM bone marrow, MBCP scaffold, DPSCs dental pulp mesenchymal stem cells, Mel melatonin)

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Stem Cell Research & Therapy

ISSN: 1757-6512