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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects

Fig. 6

Effects of melatonin (0, 100, 10, and 1 μM) on ALP, BMP-2, OCN, and RUNX2 gene expression in DPSCs at 3 days after incubation with and without osteogenic differentiation medium. Gene expression was measured using real-time PCR. Gene expression was normalized to GAPDH. a ALP, b BMP-2, c OCN, d RUNX2. (GM growth medium, OM osteogenic medium, Mel melatonin) (*p < 0.05, **p < 0.01)

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Stem Cell Research & Therapy

ISSN: 1757-6512