Table 2 The application of BMSCs in vitro
From: Application of stem cells in the repair of intervertebral disc degeneration
Year | Team | Source of stem cells | Results |
|---|---|---|---|
2014 | Lehmann et al. [46] | Human BMSCs + Human NP cells | BMSCs differentiate into NP cells in indirect co-culture group, and form tunneling nanotubes structure which can promote the differentiation of BMSCs in direct co-culture group |
2015 | Cao et al. [42] | Rabbit BMSCs + rabbit NP cells | NP cells matrix degenerate delay, TGF-β expression↑, inhibit NF-KB signaling pathway |
2017 | Zhou et al. [43] | Rabbit BMSCs/ADMSCs + AF cells | COL I, COL II and proteoglycan content↑ in both two group, MSCs differentiate into AF cells in both two group, BMSCs perform better than ADMSCs |
2017 | Lu et al. [47] | Human NP-exos + human BMSCs | BMSCs differentiate into NP cells, ECM↑ |
2018 | Zhan et al. [37] | Rat BMSCs + Fasudil | Activate MAPK signaling pathway, promote BMSCs migration, improve the homing ability of BMSCs |
2018 | Cheng et al. [48] | Human BMSCs-exos + NP cells | Activate PI3K/AKT signaling pathway to inhibit NP cells apoptosis induced by TNF-α |
2019 | Li et al. [44] | Rat BMSCs + rat NP cells | COL II content↑, MMP9 synthesis↓, β-galactosidase expression↓, inhibiting NF-KB signaling pathway can slow the aging of NP cells |
2019 | Li et al. [45] | Pig BMSCs + pig NP cells ECM | BMSCs differentiate into NP cells |
2019 | Xia et al. [49] | Human BMSCs-exos + NP cells | Inhibit the activation of inflammatory mediators and NLRP3 inflammasome |